Endocrine Abstracts

Introduction: Diabetes is a major risk factor for chronic kidney disease (CKD). Previous studies have shown contradictory results regarding the effect of prediabetes in the development of CKD.Methods: We performed a secondary analysis of the SPRINT trial (Systolic Blood Pressure Intervention Trial) involving 9361 patients without diabetes and with an increased cardiovascular risk (clinical or subclinical cardiovascular disease, estimated glomerular filtr...

BackgroundGraves’ Disease (GD) is characterized by production of stimulating autoantibodies to thyrotropin receptor resulting in hyperthyroidism. Hyperthyroidism is associated with insulin resistance, hyperglycemia and ketosis. Our aim was to evaluate if single nucleotide polymorphism (SNP) in pro-inflammatory cytokines contributes to dysglycemia in GD.MethodsWe evaluated 98 patients with Graves’ di...

Introduction: Graves’ disease is an autoimmune disease accounting for the majority of hyperthyroidism cases.Aim: We aimed to assess the interrelationships between cardiovascular risk factors, autoimmunity, insulin resistance and treatment in Graves’ disease.Material and methods: We measured free T3 (FT3), free T4 (FT4), TSH, thyrotropin receptor antibodies (TRAb), anti-thyroglobulin and anti-TPO antibodies, thyro...

Introduction: Thyroid dysfunction has been associated with cardiovascular events since it worsens atherogenesis, insulin resistance and dyslipidemia. Thyroid hormones and adipokines interact with each other to regulate metabolism. The impact of thyroid dysfunction on adipokines serum levels remains controversial.Objective: To evaluate the interrelations between thyroid function and cardiovascular risk factors as insulin resistance, lipid profile, inflamm...

Introduction: The interrelationship between autoimmune thyroiditis, Graves’ disease and plasma adipokines levels remains elusive.Aims: We aimed to compare the levels of adiponectin, resistin and PAI-1 levels in patients with autoimmune thyroiditis and Graves’ disease.Subjects and methods: We recorded thyroid function tests, BMI, the levels of total cholesterol (TC), HDL, LDL-cholesterol, triglycerides (TG), apolipoprotein...

Introduction: Positive radiotracer uptake by the thyroid gland can occur in PET-CT. It’s meaning has led to conflicting results mainly resulting from small studies.Objective: We aim to present a large single institution consecutive case series.Material and methods: Observational, descriptive and retrospective study of the PET-CT scans performed between the years 2000–2017. We searched the word thyroid in the computer imag...

Background: Overt thyroid dysfunction is associated with an increased cardiovascular risk. The impact of subclinical hypothyroidism and autoimmunity in the increased cardiovascular risk remains controversial. Aim: To evaluate the interrelations between thyroid function, thyroid autoimmunity and cardiovascular risk factors, in patients with autoimmune thyroiditis (AIT).Methods: 353 subjects with AIT were evaluated. We defined three groups based on TSH lev...

Introduction: Cushing’s syndrome is an endocrinopathy characterized by glucocorticoids excess. Adrenalectomy is the recommend treatment for unilateral adrenal Cushing’s syndrome and is usually associated with resolution of the disease.Clinical Case: A 54-year old woman with central obesity (BMI 34.3 kg/m2), diabetes and hypertension had a left adrenal mass of 15 mm and characteristics suggestive of adenoma (Hounsfield unit of <10...

Introduction: Adrenal tumors are usually detected due to clinical manifestations of hormonal hypersecretion or incidental findings on imaging evaluation. Although most incidentalomas are non-functioning adenomas, it is important to appropriately evaluate such masses to exclude hormonal excess or malignancy.Case description: An 81-year old male was admitted to our hospital for fever with 15 days of evolution. The patient also presented chills and loss of ...

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy with a poor prognosis. Hormone-secreting ACC appear with manifestations of virilization, feminization or Cushing syndrome.Case Report: A 63-year-old woman with no pathological history of relief was referred to Endocrinology evaluation with an history of deepening of the voice since 1-year ago, as well as hair loss and facial and abdominal hirsutism with 6-month evo...